Det är intressant, och det utlöste en flod av kommentarer, men jag tänker ändå inte gå in i en kinarestaurang igen. Anledningen till att asiater klarar glutamat bättre än många européer är att de börjar sin måltid med kolhydrater, vilket upphäver det skadliga effekten, skrev Blaylock.
Alltfler ”kända personer” drabbas av Alzheimers och Parkinsons, president Reagan den mest kända. Vore intressant om någon kunde lista ut dessa patienters matvanor under 10-15 år innan de drabbades. Epidemiologisk anamnes?
Följande kommentar och svar tycker jag var intressant.
1. John says:
February 22nd, 2007 at 4:18 am
Mike, have you read Excitotoxins: The Taste that Kills by Russell Blaylock?
His credentials seem solid and he believes MSG is neurotoxic, as it crosses the blood-brain barrier and “over excites” neurons. I’d be interested if it does (or obviously hasn’t) changed your thoughts on this subject.
Yes, I’ve read Excitotoxins. And I found Dr. Blaylock’s arguments convincing until I dug a little deeper. It turns out that glutamate does indeed ‘excite’ neurons, and does so by allowing calcium to enter the cells. This excitation of the neuron is offset by the ‘calming’ influence of GABA, which acts in opposition to glutamate. The GABA-glutamate axis in the brain is much like the insulin-glucagon axis in the metabolic system. One needs both to function properly.
Since the tiny bit of MSG used to season foods breaks down into glutamate and sodium – both normal constituents of the human body, and, in the case of glutamate, actually made by the human body – it’s difficult for me to image how a little bit of glutamate added to the body’s large circulating stores could substantially influence the neurons. If taken in large amounts, perhaps, but a pinch, occasionally, I don’t think will hurt. And maybe if a person is deficient in magnesium there could be a problem. Magnesium is Nature’s calcium channel blocker, so inadequate magnesium might not offset the influx of calcium driven by glutamate. This is just a hunch, but, because – according to the latest survey I read – about 75 percent of Americans don’t even get the already-too-low RDI of magnesium, maybe it’s the widespread magnesium deficiency that allows whatever negative effects experienced by some people when consuming a lot of MSG to happen. I don’t have magnesium consumption figures at hand for the Japanese, but given what they eat, I would assume they get a lot more magnesium in the standard Japanese diet compared to what we do in the standard American diet.
The strongest argument for the harmlessness of MSG is the fact that it’s used in such large quantities in Asia by enormous numbers of Asians without any apparent epidemic of negative effects. The Japanese, for example, use MSG (and believe it’s healthful) in large quantities and outlive everyone else on earth despite the fact that most of them smoke. And they’re blowing the tops out of all the admission processes in American colleges, leaving US students in the dirt, so it can’t be affecting their cognitive abilities. If MSG were truly harmful, I would suspect the Japanese would suffer its ill effects. But, again, perhaps the greater intake of magnesium by the Japanese is protective. Which may be why they live longer, after all.